Our findings suggested that the peripheral immunological cell levels reflect the patient’s condition. · Ethnopharmacological relevance: The Th1/Th2/Th17/Treg paradigm plays an important role in achieving maternal-fetal immunotolerance and participates in RU486-induced abortion. Th1/Th2/Th17/Treg Balance in Apical Periodontitis of Normoglycemic and Diabetic Rats J … 2017 · Th1、Th2、,精品论文 参考文献 Th1、Th2、Th17和Treg研究现状 张文林1（通讯作者） 张建军2 姚明荣3 母存富1 张熠1 （1广元市第一人民医院心胸外科 四川广元 628017） （2广元市第一人民医院感染科 四川广元 628017） （3广元市 … 2016 · 3 Th1／Th2细胞与肿瘤微环境的关系3．1 Th1／Th2细胞在肿瘤微环境中的发育 辅助性T细胞从功能上细分为Th1细胞和Th2细胞，在肿瘤微环境里扮演着不可或缺的角色，进而影响着肿瘤的发生发细胞分化为Th1和Th2细胞在免疫应答中起关键性的作用。. 12. The net effects of Th cytokines determine the direction of immune responses … 2023 · The balance of Th1/Th2 and Th17/Treg cells was analyzed by Flow cytometry. DNA corresponding to pe35, esxa, esxb, rv2346c, rv2347c, rv3619c, and rv3620c genes were cloned into the expression vectors pGES-TH-1, pDE22 and pUMVC6 for expression in … 2010 · CD4 + T helper (Th) cells are essential effectors of the immune response and play an important role in inflammation. CD4 + Th细胞有不同的亚群 ，包括 Th1, Th2, Th9, Th17, Th22, Tfh 和 Treg 细胞，每个亚群都由一组特定的细胞因子和转录因子活化，分泌细胞因子并发挥效应功能。 Th2细胞介导针对细胞外寄生虫、细菌、过敏原和毒素 … The inferred pseudotime paths revealed the developmental trajectory of CD4 + Tn/Tnra cells to Th cell clusters including Th1, Th17-like, and Treg cells (Fig. 2016 · 所以，目前认为，IL-23 Th17细胞存活、增殖、功能维持的重要因子[7]。 IL- 2是T细胞生长因子，在维持和促进Th1、Th2、 Treg细胞及 CD8+ T细胞功能活性方面发挥着关键作 用。而值得注意的是，研究发现 IL- Th17细胞分 化的抑制因素。 2015 · CD4 + T, termed as T helper (Th) cells, are a heterogeneous group and can differentiate into Th1, Th2, Th17, Treg, and many other Th cells. CD4 T helper cells can be divided into at least four lineages, namely, Th1, Th2, Th17 and Treg.For example, in the presence of interleukin (IL)-6 or IL-21 (together with TGF-β), naïve CD4 + T cells … 2020 · 流式细胞术检测人外周血Th1、Th17细胞有两种主要方法，一种主要是根据细胞表面标记，如CXCR3、CCR6、CD161，比较节省时间，但这些标记不是Th1、Th17特异性的，故容易导致比例增多，另一种则根据表面和胞内染色，通过体外培养刺激，促进细胞分泌 … Our data suggest that the cytokine balance is broken, encouraging the development of an exacerbated inflammatory response. In CLBP, however, specific alterations in the adaptive immune system have not conclusively been analyzed, yet. 2021 · The Th1 cell-specific cytokine interferon gamma (IFN-γ) promotes Th17 differentiation, while the Th2 cell-specific cytokine IL-4 inhibits the differentiation .
These cells express master transcription factors (shown inside the cells, pSTATs . To assist investigations into the transcriptional identity and regulatory processes of these cells we performed mRNA-sequencing on three murine T helper subtypes (Th1, Th2 and Th17) as well as on . Subsequent to a 48‑h incubation, PBMCs … 2022 · 目前已确定了5种主要的辅助T细胞亚群：Th1、Th2、Th17、Treg（调节性）和Tfh（滤泡辅助）细胞。致病辅助T细胞的失衡（图1）如Tfh细胞不受控制的扩增、CD4 + 和CD8 + T细胞的减少和功能缺失等都与SLE发病有关。图1 辅助T细胞的失衡 2. 2009 · T helper lineages and subsets.08. Differentiation of Treg cells and Th17 cells requires the involvement of the TGF-β- regulated signalling pathway [].
Peripheral mononuclear cells (PBMCs) were isolated from healthy donors, and incubated with aPLs. 四川大学学报（医学版）, 2014, 45(6): 946-949. (一)CD30 CD30抗原属 TNF受体超家族成员，最早作为Reed-Sternberg细胞的特异标志物，也见于活化的T细胞和B细胞。. STAT3 is required for the induction of RORγt. Open in a separate window. Recent reports suggest functional deviation of T(regs) in terms of producing IL-17A, a process that may be aberrant in SLE.
아두 이노 로봇 팔 [2]. Th1: Although NFAT was originally identified to play important roles in the activation of T cells, it has also been shown that NFAT proteins differentially affect T helper (Th) cell differentiation (Figure 2) (37–41). 2015 · 主要集中在Th1,Th2细胞亚群,近年来研究表明,Th17 细胞是诱导自身免疫性葡萄膜炎发病的主要原因,而 Treg细胞是负向调控葡萄膜炎的主要因素。因此,Th17 和Treg细胞在葡萄膜炎的发病及病程演变过程中发挥 重要作用,本文就Th17细胞、Treg细胞与自身免疫性葡. Th1- and Th2-cells have the capacity to … 一、Th1/Th2细胞的特异性表面标志. There is a regulatory relationship between Th17 cells and the induction and differentiation of Th1 cells, Th2 cells, and Treg cells. The BD Human Th1/Th2/Th17 Phenotyping Kit provides an easy-to-use four-color cocktail of fluorescent antibodies-specific for human CD4, IFN-γ (for Th1), IL-4 (for … In conclusion, our study showed an imbalance in cell mediated immune response and disturbance in Th1/Th2/Th17 and T reg population of T helper cells and also the shifts … Abstract.
One-way ANOVA is used to compare multiple n Correlation analysis is used for the correlation analysis. Considering the … 2018 · CD4 + T cells differentiate into subsets such as Th1, Th2, Th17, Treg, Th9, Th22, and T follicular helper cells 1 cells rely on the expression of T-bet and eliminate intracellular pathogens . Th17 gets it name by the associated interleukin., malignant cells). Our results show that there is a shift, in the Th1/Th2, and the Th17/Treg balance, favoring skewness towards a proinflammatory status in the umbilical cord blood in preeclampsia … 2012 · 目的：比较采用3种不同方法在体外诱导CD4细胞向Th17细胞分化与增殖的效率。. Cells were assessed for of Gli1 mRNA expression on day 3 (Th17, left) or harvested for flow cytometry on day 5 (right). Th1/Th2/Th17/Treg Balance in Apical Periodontitis of The concept of T helper 1 (Th1) and Th2 dichotomy was proposed in 1986 by Mosmann et al. Th17-cells, a more recently described T-helper cell subset, are characterized by their ability to produce interleukin-17A (IL-17A) [9]. The skew ratio .H-2h4 mice Biol Trace Elem Res. Key findings: THDCA significantly alleviated colitis by improving the body weight, colon length, spleen weight, histological characteristics, and MPO activity of colitis mice. 2011 · T-helper cells are defined as Th1-, Th2- or Th17-cells characterized by differential expression of certain cytokines.
The concept of T helper 1 (Th1) and Th2 dichotomy was proposed in 1986 by Mosmann et al. Th17-cells, a more recently described T-helper cell subset, are characterized by their ability to produce interleukin-17A (IL-17A) [9]. The skew ratio .H-2h4 mice Biol Trace Elem Res. Key findings: THDCA significantly alleviated colitis by improving the body weight, colon length, spleen weight, histological characteristics, and MPO activity of colitis mice. 2011 · T-helper cells are defined as Th1-, Th2- or Th17-cells characterized by differential expression of certain cytokines.
联科生物 - ELISA试剂盒, 流式抗体, 细胞凋亡、周期、 Th1
To explore whether Th1/Th2/Th17/Treg paradigm plays an important role in the development of T2DN, we investigated the proportions of Th1/Th2/Th17/Treg cells and serum levels of relevant cytokines in T2DM patients with various degrees of nephropathy … 2023 · DOI: 10. However, the natural history of clearance of a cervical HPV infection or its progression to a UCC needs clarification. There are distinct subsets of CD4 + Th cells, including Th1, Th2, Th9, Th17, Th22, Tfh, and Treg cells, each activated by a specific set of cytokines and transcription factors and … 2023 · The Th1/Th2/Th17 paradigm provides a useful model system for investigating the cellular and molecular mechanisms that mediate protective as well as harmful immune responses. The circulating levels of each subset of CD4+ T cells were analyzed by flow cytometry, and the results showed that Th1, Th9, Th17, and Th22 levels were significantly increased in AD patients compared with the levels in NAD patients (Figures 1(a) and 1(c)), while lower … 2023 · ARG80933 Human Th1/Th2/Th17/Treg Multiplex ELISA 试剂盒 (IFN gamma, IL2, IL4, IL10, IL13, IL17A, IL22, TNF alpha) is an Enzyme Immunoassay kit for the semi-quantification of IFN gamma, IL2, IL4, IL10, IL13, IL17A, IL22 and TNF alpha in serum, plasma and cell culture all Multiplex ELISA 试剂盒 2021 · T cells have been demonstrated to exert central roles in the development of type 2 DN (T2DN). 2020 · Failures to maintain adequate Th1/Th2 and Th17/Treg cell balance are associated with RPL, RIF, and 2nd and 3rd-trimester complications. 2020 · Besides the level of Th1/Th2 cytokines, the imbalance in Th17/Treg is believed to lead to the development of various autoimmune and inflammatory diseases.
Notably, Metascape … Dysbalance of T-helper-cell (Th) subsets (Th1/Th2/Th17) and regulatory T-cells (T(regs)) is suggested to contribute to the pathogenesis of SLE. TH17 cells play an important pro-inflammatory role whereas Tregs are strong immune suppressors. n = 4 mice per genotype. 2020 · Our results suggested that cytokines act in a cell type specific manner to induce five cell states in T N (Th1, Th2, Th17, iTreg, and IFN-β) and three in T M (Th1, … 2022 · Abstract: ObjectiveTo investigate the predictive value of peripheral blood Th1/Th2 and Treg/Th17 cytokines on the short-term prognosis of patients with severe sepsis. 方法：分别采取以下3种方法体外诱导Th17细胞：给予CD3及CD28抗体刺激，并在培养体系中加入白细胞介素6及转化生长因子β，培养3d。. The BD Mouse Th1/Th2/Th17 Phenotyping Kit provides an easy-to-use four-color cocktail of fluorescent antibodies-specific for mouse CD4, IFN-γ (for Th1), IL-4 (for Th2) … The imbalance of Th1/Th2 and Th17/Treg cells was related to the UCC stage, tumor size, lymph node metastases, and vasoinvasion.Yadongjoanbi
Immunological cell levels normalized sooner in CIN patients than in UCC patients after operations. The inflammatory profile of AP in DM is different from that in the N group, suggesting that Th1 is a secondary strain and the Th17 strain is predominant in DM. 2010 · Wei et al. TH17 cells: with the signature cytokine being IL-17 thus giving its name takes … 【摘要】：CD4~+T细胞在不同细胞因子环境中可分化为Th1、Th2、Treg、Th17四种亚群,在一定条件下,各Th细胞亚群之间可以互相转化,从而使机体的免疫效应和免疫抑制处于精细而复杂的平衡状态。Th17细胞与自身免疫性疾病和肿瘤的发生发展关系密切,研究Th17 . Results: DSS-resistant BALB/c mice were characterized by low levels of IFN-γ … 2020 · The correlation between Treg cells and Th17 cells. We examined the related immune cells (Th1, Th2, Th17 and Treg cells) and related immune factors (INF-γ, IL-4, IL-10, IL … 2022 · Th1的诱导需要加入IFN-Y、IL-12与抗IL-4，而Th2的诱导需要加入IL-4、抗IFN-y与抗IL-12。 在相应的培养条件下诱导4天以上即可培养出相应的Th1或Th2细胞。 Th17细胞的分化诱导的基本原理是先将Th0细胞进行活化，同时加入TGF-β、IL-6、抗IFN-y和抗IL-4等相应的条件促进Th17的分化。 The following protocols describe the methods to induce naïve CD4+ T-cell differentiate into Th1, Th2, Th17 and Treg by activating TCR, together with the different cytokines and blocking antibodies in vitro.
The Th17/Treg Balance in Autoimmunity. Sep 6, 2018 · Methods: Blood samples from AD (n = 56) and non-AD (NAD, n = 24) patients were collected, and the circulating levels of Th1, Th2, Th9, Th17, Th22, and Treg cells and their transcription factors and functional cytokines were measured by flow cytometric analysis, quantitative polymerase chain reaction, and enzyme-linked immunosorbent … 2020 · Interestingly, the ratios of Th1/Th2 cells as well as Treg/Th17 cells were skewed towards a pro-inflammatory phenotype in our ALS … 2020 · CD4+ T细胞是一群高度异质性细胞，自1986年Mosmann等揭开了Th1, Th2亚群的神秘面纱后，其他科学家又陆续发掘了Th3,Treg,Tr1,Tfh,Th17,Th9和Th22等CD4+ … 2021 · Our study demonstrated that the Th1/Th2/Th17/Treg paradigm skewed to Th1 and Th17 in T2DN patients.However, in different cytokine environments, the differentiation direction of CD4 + T cells can be … 2020 · CD4+亚群（Th细胞）根据自身所分泌的细胞因子，分为Th1和Th2两个亚群。Th1细胞主要分泌IL-2、IFN- γ和TNF-β 等细胞因子。Th1细胞主要介导细胞免疫反应， … In conclusion, our study showed an imbalance in cell mediated immune response and disturbance in Th1/Th2/Th17 and T reg population of T helper cells and also the shifts towards Th2 and T17 in THS patients who had developed sepsis and showed poor outcomes. Predominately identified CD4+T cell subsets, Th1, Th2, Th17, as well as regulatory T (Treg) cells, play crucial roles in several immunological and pathological conditions. 2021 · Tumor-specific T helper (Th) cells have a central role in the immune response against cancer. · 1.
3 A). Therefore, the balance between TH17 cells and Tregs, along with TH1/TH2 balance, is an important factor in analyzing the immune response. However, there exist distinct Th cell subsets with very different and antagonizing properties. Circulating Th1, Th2, Th9, Th17, Th22, and Treg Cells in AD Patients. I’ve only been researching the area of immunology and autoimmune disease since June 2018 (in contrast, I’ve been researching … 2019 · The immune function of Th2 cells in pathogenic infection is mainly to induce humoral immunity.2. 05). No. 2013 · Th1, Th2, Th17 and Treg cells antagonize each other by releasing their effector cytokines. Differentiation of naive Th cells into Th1, Th2 or Th17 effector cells occurs within a few days of direct contact with APCs. The Th1 cells belong to populations of pro-inflammatory immune cells that … The relationships between Th1/Th2/Th17/Treg and Th3, Tr1, Th9, Tfh cells are shown in Figure 1.065 Corpus ID: 260982281; The role of Th17 and Treg cells in normal pregnancy and unexplained recurrent spontaneous abortion … Mechanisms of T-cell polarization. Microsoft 계정 삭제 v9vmtc CD4 + T cells are the common precursor cells of Treg cells and Th17 cells.Subsequently, the Th1/Th2 paradigm was adopted to explain maternal tolerance toward fetal alloantigens during pregnancy by Wegmann et al. Th17 specific transcription factor is retinoic acid receptor-related orphan receptor γ (RORγt) . The food and water consumption, locomotor activity and MPT of group C declined than those of group S and M on d1, d2, d3 (P < 0. Materials and Methods: Participants were divided randomly into two groups of 41 men in the WCT group and 40 men in the DCT group. The signaling networks of Th1, Th2, and Th17 mediated by specific cytokines are regulated by Treg cells to maintain immune homeostasis. Disrupted TH17/Treg Balance in Patients with Chronic Low
CD4 + T cells are the common precursor cells of Treg cells and Th17 cells.Subsequently, the Th1/Th2 paradigm was adopted to explain maternal tolerance toward fetal alloantigens during pregnancy by Wegmann et al. Th17 specific transcription factor is retinoic acid receptor-related orphan receptor γ (RORγt) . The food and water consumption, locomotor activity and MPT of group C declined than those of group S and M on d1, d2, d3 (P < 0. Materials and Methods: Participants were divided randomly into two groups of 41 men in the WCT group and 40 men in the DCT group. The signaling networks of Th1, Th2, and Th17 mediated by specific cytokines are regulated by Treg cells to maintain immune homeostasis.
누누tv 2022 CD4 + Th细胞有不同的亚群，包括Th1, Th2, Th9, Th17, Th22, Tfh 和 Treg细胞，每个亚群都由一组特定的细胞因子和转录因子活化，分泌细胞因子并发挥效应功能。Th2细胞介导针对细胞外寄生虫、细菌、过敏原和毒素的体液或抗体介导的免疫反应的活化和维持。 2018 · Four color separation flow cytometry instrument is used to test percentage of Th1 、 Th2 、 Th17 and Treg in peripheral dent T test is used to compare the mean difference between the two groups. Th1, Th17, and Treg cell immunity was predominant in the acute stage, while Th2, Th17, and Treg cell … Th17 cells are not terminally differentiated cells, they can switch into Th1 cells and may be implicated in several inflammatory reactions such as production of production of pro-inflammatory cytokines and chemokines leading to recruitment of neutrophils and macrophages. 1型和2型Th（Th1和Th2）细胞、Th17细胞和效应性T（Treg）细胞的强分化途径已得到确认。 Tfh细胞分化需要多种因素共同促成，而非单一事件的结果[1]。 人们普遍认为，Tfh的分化需要在IL-6和IL-21同时存在的情况下，用MHC II特异性多肽刺激naive CD4 + T细胞TCR[ 11、12、13 ]。 Regulation of Th1/Th2 and Th17/Treg by pDC/mDC imbalance in primary immune thrombocytopenia This study investigates the regulatory effect of plasmacytoid dendritic … 2015 · 3. However, the effect of arsenic-induced neuroimmune toxicity has rarely been reported. Th9/Th17/Th22/Treg Cytokine: IL-9 [52], IL-10 [28], IL-17A (CTLA-8) [36], IL-22 [76], IL-23 [63], IL-27 [14] About ProcartaPlex assays for the Luminex platform ProcartaPlex immunoassays are based on the principles of a sandwich ELISA, using two highly specific antibodies binding to different epitopes of one protein to quantitate all protein . The role of Th1, Th2, and Th17 cells in asthma exacerbation.
2021 · In ASD, several studies reported changes in peripheral blood lymphocyte subsets such as reduced total number of lymphocytes, impairment of the CD4/CD8 T cell ratio, a defective activation of T cells, an increased number of the natural killer (NK) cells, an imbalance of the Th1/Th2 cytokines but also some aberrations in cytotoxicity related to . The aim of this study was to evaluate the expression of T-helper cell subtypes Th1, Th2, Th17 and Treg in antiphospholipid syndrome (APS), and whether they are related to … 2023 · 产品描述 ARG82914 arigoPLEX ® Mouse Th1/Th2/Th17/Treg Cytokines Multiplex ELISA Kit (IFN gamma, IL4, IL17, IL10) is an Enzyme Immunoassay kit for the semi-quantification of IFN gamma, IL4, IL17, IL10 in serum, plasma and cell culture supernatant. Th17 Cells in TB Defense and Pathology. See all Multiplex ELISA kits 2014 · Treg/Th17细胞、钙卫蛋白在溃疡性结肠炎模型大鼠血清及肠组织中的表达变化[J]. The growth and development of Th17 cells are negatively regulated by IFN-gamma and IL-4. 2013 · Th17- 2013-08-09 上传 Th17-Treg平衡调节与疾病的关系研究进展综述,研究,平衡,Th17,疾病的关系,关系,疾病进展,Treg,和Treg,平衡研究 2020 · 按图A中箭头所示顺序，在前侧向图中圈出淋巴细胞，去除死细胞后，圈出CD3+的T细胞亚群，再分别圈出CD4+和CD8+亚群，接下来用CXCR3，CCR4，CCR6，CD161，CD25， CD127等表面标记，进一步区分Th1，Th2， Th17，Treg等感兴趣的细胞亚群。 2023 · Th/Treg分型检测试剂盒 定制Human Th1/Th2/Th17 staining kit II ¥ 说明书 在售SKU:70-KTH002-100, 70-KTH002-25, KTH002, th1, th2, 染色, Th, 分型, 细胞分型, 免疫分型, 检测, 分型检测, 试剂盒 Sep 6, 2018 · Methods.
The results suggest that both GATA-3/T-bet and RORγt/Foxp3 ratios were significantly higher in PBMCs collected from two asthma … 调节性T细胞（Treg）及其流式检测方法. Aim: Imbalance of T-helper-cell (TH) subsets (TH1/TH2/TH17) and regulatory T-cells (Tregs) is suggested to contribute to the pathogenesis of Systemic lupus … 2020 · The ratio of CD4+/CD8+, proportions of Th1, Th2, Th17 and Treg cells in blood were detected using flow cytometry. 在方法的基础上加入白细胞介素1β及肿瘤坏死因子α . THDCA reduced the secretion of Th1-/Th17-related cytokines (IFN-γ, IL-12p70, IL-6, IL-17A, IL . for the first time [1]. A Th17 dominance or dysfunctional Treg surveillance is associated with … Sep 1, 2019 · This indicated that immunoregulation may play a central role in the HPV-induced carcinogenesis. What are Helper T Cells (CD4+, Th1, Th2, Th17,
Cytokine bead assay; Multiple organ failure; Trauma hemorrhagic shock. 8 Th17 cells, which produce the proinflammatory cytokine, IL-17, play important roles for the induction of inflammation. The control of this disease requires appropriate preventive measures, including vaccines. 2018 · NFAT in T Cell Subsets: Th1, Th2, Th17, Treg, And Tfh. BMC Womens Health 20 (1), 126 (2020). Uncommitted (naive) murine CD4+ T helper cells (Thp) can be induced to differentiate towards T helper 1 (Th1), Th2, Th17 and regulatory (Treg) phenotypes according to the local cytokine milieu.고흐 아이리스
Abstract. Since the discovery of the Th1/Th2 dichotomy, many additional Th subsets were discovered, each with a unique cytokine profile, functional properties, and presumed role in … Sep 6, 2018 · 3. 2019 · 在T细胞受体（T cell receptor，TCR）激活后，初始的T细胞可以在不同的细胞因子影响下分化为至少4种以上的T细胞亚群：Th1、Th2、Th17、调节性T细胞（regulatory T cell，Treg）等，它们参与各种各样的免疫应答反应，在不同的疾病中起到不同的作用，功能 2014 · Due to the antagonistic functions of TH17 and Treg cells, and in analogy to the well-known TH1/TH2 paradigm, the ratio between TH17 and Tregs is increasingly used to characterize immune responses. This can be demonstrated most readily both in vitro and in vivo in murine CD4+ T cells.T细胞活化异常 · A tug of war between destructive immune cells (Th1/Th17) and protective or immuno-tolerant cells (Treg cells) operates in human body in an attempt to clear … 2023 · The Th1/Th2/Th17 paradigm provides a useful model system for investigating the cellular and molecular mechanisms that mediate protective as well as harmful immune responses. 2018 · Accordingly, the aim of this study was to evaluate the plasma levels of cytokines expressing the Th1, Th2, Th17 pattern, as well as Treg cytokines, TNF-alpha, IL-1β, IL-8, IL-7 in patients with SAH-CCHD to get insight into the immunomodulation process in patients with this condition.
2018 · To further characterize the effect of Treg cells depletion on T cell subsets, the mRNA expression for transcription factors and cytokines of Th1, Th2, Th17 and Treg cells was measured by RT-PCR in . Th17 were first described as a distinct population of the T helper cells that are controlled by the transcription factor ROR γ t and develop independent of T-bet, STAT4, GATA-3, and STAT6 transcription factors that are critical for the Th1 and Th2 development [ 50, 51 ]. 引用本文: 王坤, 宣秀敏, 王莲等. Sep 30, 2020 · 原文丨董晨、Casey T Weaver 经典的免疫学教材将辅助性T细胞（helper T cell）分为Th1，Th2，Th17，滤泡辅助性T细胞（Tfh），调节性T细胞（Treg）五类。2005年，清华大学免疫学研究所董晨教授与Casey T Weaver教授于在Nature Immunology背靠背发文报道了Th17细胞的发现，这一发现打破了免疫学家二十多年来对辅助性T . The T cell compartment can form a powerful defense against extrinsic (e. UACR was positively related to the proportions of Th1 and … Sep 28, 2019 · 与Th1和Th2类似，Th17和Treg之间也可相互转化且有一个动态平衡。 初始T淋巴细胞分化为促炎的Th17或免疫抑制的Treg取决于微环境的细胞因子; TGF-β可诱导FoxP3，抑制IL-17A和ROR-γt的表达; 而IL-6和TFG-β可协同诱导初始T淋巴细胞表达IL-23R和ROR-γt，进而促进Th17分化，同时IL-6也可抑制Foxp3表达 [ 26 ] 。 Th1, Th2, Th17, and Treg cells - Four pillars of an immune system in balance.
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